// version 1.2.21 typealias DList = List enum class Direction { UP, DOWN } // test also for 'Unknown' correction type val types = listOf( "Benjamini-Hochberg", "Benjamini-Yekutieli", "Bonferroni", "Hochberg", "Holm", "Hommel", "Šidák", "Unknown" ) fun adjusted(p: DList, type: String) = "\n$type\n${pFormat(adjust(check(p), type))}" fun pFormat(p: DList, cols: Int = 5): String { var i = -cols val fmt = "%1.10f" return p.chunked(cols).map { chunk -> i += cols "[%2d] %s".format(i, chunk.map { fmt.format(it) }.joinToString(" ")) }.joinToString("\n") } fun check(p: DList): DList { require(p.size > 0 && p.min()!! >= 0.0 && p.max()!! <= 1.0) { "p-values must be in range 0.0 to 1.0" } return p } fun ratchet(p: DList, dir: Direction): DList { val pp = p.toMutableList() var m = pp[0] if (dir == Direction.UP) { for (i in 1 until pp.size) { if (pp[i] > m) pp[i] = m m = pp[i] } } else { for (i in 1 until pp.size) { if (pp[i] < m) pp[i] = m m = pp[i] } } return pp.map { if (it < 1.0) it else 1.0 } } fun schwartzian(p: DList, mult: DList, dir: Direction): DList { val size = p.size val order = if (dir == Direction.UP) p.withIndex().sortedByDescending { it.value }.map { it.index } else p.withIndex().sortedBy { it.value }.map { it.index } var pa = List(size) { mult[it] * p[order[it]] } pa = ratchet(pa, dir) val order2 = order.withIndex().sortedBy{ it.value }.map { it.index } return List(size) { pa[order2[it]] } } fun adjust(p: DList, type: String): DList { val size = p.size require(size > 0) when (type) { "Benjamini-Hochberg" -> { val mult = List(size) { size.toDouble() / (size - it) } return schwartzian(p, mult, Direction.UP) } "Benjamini-Yekutieli" -> { val q = (1..size).sumByDouble { 1.0 / it } val mult = List(size) { q * size / (size - it) } return schwartzian(p, mult, Direction.UP) } "Bonferroni" -> { return p.map { minOf(it * size, 1.0) } } "Hochberg" -> { val mult = List(size) { (it + 1).toDouble() } return schwartzian(p, mult, Direction.UP) } "Holm" -> { val mult = List(size) { (size - it).toDouble() } return schwartzian(p, mult, Direction.DOWN) } "Hommel" -> { val order = p.withIndex().sortedBy { it.value }.map { it.index } val s = List(size) { p[order[it]] } val min = List(size){ s[it] * size / ( it + 1) }.min()!! val q = MutableList(size) { min } val pa = MutableList(size) { min } for (j in size - 1 downTo 2) { val lower = IntArray(size - j + 1) { it } // lower indices val upper = IntArray(j - 1) { size - j + 1 + it } // upper indices var qmin = j * s[upper[0]] / 2.0 for (i in 1 until upper.size) { val temp = s[upper[i]] * j / (2.0 + i) if (temp < qmin) qmin = temp } for (i in 0 until lower.size) { q[lower[i]] = minOf(s[lower[i]] * j, qmin) } for (i in 0 until upper.size) q[upper[i]] = q[size - j] for (i in 0 until size) if (pa[i] < q[i]) pa[i] = q[i] } val order2 = order.withIndex().sortedBy{ it.value }.map { it.index } return List(size) { pa[order2[it]] } } "Šidák" -> { val m = size.toDouble() return p.map { 1.0 - Math.pow(1.0 - it, m) } } else -> { println( "\nSorry, do not know how to do '$type' correction.\n" + "Perhaps you want one of these?:\n" + types.dropLast(1).map { " $it" }.joinToString("\n") ) System.exit(1) } } return p } fun main(args: Array) { val pValues = listOf( 4.533744e-01, 7.296024e-01, 9.936026e-02, 9.079658e-02, 1.801962e-01, 8.752257e-01, 2.922222e-01, 9.115421e-01, 4.355806e-01, 5.324867e-01, 4.926798e-01, 5.802978e-01, 3.485442e-01, 7.883130e-01, 2.729308e-01, 8.502518e-01, 4.268138e-01, 6.442008e-01, 3.030266e-01, 5.001555e-02, 3.194810e-01, 7.892933e-01, 9.991834e-01, 1.745691e-01, 9.037516e-01, 1.198578e-01, 3.966083e-01, 1.403837e-02, 7.328671e-01, 6.793476e-02, 4.040730e-03, 3.033349e-04, 1.125147e-02, 2.375072e-02, 5.818542e-04, 3.075482e-04, 8.251272e-03, 1.356534e-03, 1.360696e-02, 3.764588e-04, 1.801145e-05, 2.504456e-07, 3.310253e-02, 9.427839e-03, 8.791153e-04, 2.177831e-04, 9.693054e-04, 6.610250e-05, 2.900813e-02, 5.735490e-03 ) types.forEach { println(adjusted(pValues, it)) } }