crule[m_, b_] := Module[{d = Det[m], a}, Table[a = m; a[[All, k]] = b; Det[a]/d, {k, Length[m]}]] crule[{ {2, -1, 5, 1}, {3, 2, 2, -6}, {1, 3, 3, -1}, {5, -2, -3, 3} } , {-3, -32, -47, 49}]