diff --git a/docs/source/pythonapi/deplete.rst b/docs/source/pythonapi/deplete.rst
index b01de477c..8423cd946 100644
--- a/docs/source/pythonapi/deplete.rst
+++ b/docs/source/pythonapi/deplete.rst
@@ -145,6 +145,17 @@ with :func:`cram.CRAM48` being the default.
    cram.CRAM48
    pool.deplete
 
+.. data:: pool.USE_MULTIPROCESSING
+
+   Boolean switch to enable or disable the use of :mod:`multiprocessing`
+   when solving the Bateman equations. The default is to use
+   :mod:`multiprocessing`, but can cause the simulation for hang in
+   some computing environments, namely due to MPI and networking
+   restrictions. Disabling this option will not utilize all processing
+   units and take a little more time.
+
+   :type: bool
+
 The following classes are used to help the :class:`openmc.deplete.Operator`
 compute quantities like effective fission yields, reaction rates, and
 total system energy.
diff --git a/openmc/deplete/abc.py b/openmc/deplete/abc.py
index 8846906b4..9d92920d5 100644
--- a/openmc/deplete/abc.py
+++ b/openmc/deplete/abc.py
@@ -887,6 +887,14 @@ class Integrator(ABC):
             Results.save(self.operator, [conc], res_list, [t, t],
                          p, self._i_res + len(self), proc_time)
             self.operator.write_bos_data(len(self) + self._i_res)
+        self._finalize()
+
+    @staticmethod
+    def _finalize():
+        # Revert the se of multiprocessing, regardless of
+        # how the integration was performed
+        global _USE_MULTIPROCESSING
+        _USE_MULTIPROCESSING = True
 
 
 class SIIntegrator(Integrator):
@@ -1021,6 +1029,9 @@ class SIIntegrator(Integrator):
                          p, self._i_res + len(self), proc_time)
             self.operator.write_bos_data(self._i_res + len(self))
 
+        # Tidy up: reset use of multiprocessing
+        super()._finalize()
+
 
 class DepSystemSolver(ABC):
     r"""Abstract class for solving depletion equations
diff --git a/openmc/deplete/pool.py b/openmc/deplete/pool.py
index d9d359775..8360ef602 100644
--- a/openmc/deplete/pool.py
+++ b/openmc/deplete/pool.py
@@ -2,10 +2,15 @@
 
 Provided to avoid some circular imports
 """
-from itertools import repeat
+from itertools import repeat, starmap
 from multiprocessing import Pool
 
 
+# Configurable switch that enables / disables the use of
+# multiprocessing routines during depletion
+USE_MULTIPROCESSING = True
+
+
 def deplete(func, chain, x, rates, dt, matrix_func=None):
     """Deplete materials using given reaction rates for a specified time
 
@@ -41,8 +46,8 @@ def deplete(func, chain, x, rates, dt, matrix_func=None):
         fission_yields = repeat(fission_yields[0])
     elif len(fission_yields) != len(x):
         raise ValueError(
-            "Number of material fission yield distributions {} is not equal "
-            "to the number of compositions {}".format(
+            "Number of material fission yield distributions {} is not "
+            "equal to the number of compositions {}".format(
                 len(fission_yields), len(x)))
 
     if matrix_func is None:
@@ -50,9 +55,12 @@ def deplete(func, chain, x, rates, dt, matrix_func=None):
     else:
         matrices = map(matrix_func, repeat(chain), rates, fission_yields)
 
-    # Use multiprocessing pool to distribute work
-    with Pool() as pool:
-        inputs = zip(matrices, x, repeat(dt))
-        x_result = list(pool.starmap(func, inputs))
+    inputs = zip(matrices, x, repeat(dt))
+
+    if USE_MULTIPROCESSING:
+        with Pool() as pool:
+            x_result = list(pool.starmap(func, inputs))
+    else:
+        x_result = list(starmap(func, inputs))
 
     return x_result