diff --git a/openmc/deplete/abc.py b/openmc/deplete/abc.py
index 5441829b40..e8f65f8871 100644
--- a/openmc/deplete/abc.py
+++ b/openmc/deplete/abc.py
@@ -23,8 +23,8 @@ class Settings(object):
     output_dir : pathlib.Path
         Path to output directory to save results.
     chain_file : str
-        Path to the depletion chain xml file.  Defaults to the
-        :envvar:`OPENDEPLETE_CHAIN` environment variable if it exists.
+        Path to the depletion chain XML file.  Defaults to the
+        :envvar:`OPENMC_DEPLETE_CHAIN` environment variable if it exists.
     dilute_initial : float
         Initial atom density to add for nuclides that are zero in initial
         condition to ensure they exist in the decay chain.  Only done for
@@ -37,7 +37,7 @@ class Settings(object):
     """
     def __init__(self):
         try:
-            self.chain_file = os.environ["OPENDEPLETE_CHAIN"]
+            self.chain_file = os.environ["OPENMC_DEPLETE_CHAIN"]
         except KeyError:
             self.chain_file = None
         self.dt_vec = None
diff --git a/openmc/deplete/chain.py b/openmc/deplete/chain.py
index 2af64e172a..2d2e71a776 100644
--- a/openmc/deplete/chain.py
+++ b/openmc/deplete/chain.py
@@ -332,9 +332,9 @@ class Chain(object):
             root = ET.parse(filename)
         except Exception:
             if filename is None:
-                print("No chain specified, either manually or in environment variable OPENDEPLETE_CHAIN.")
+                print("No chain specified, either manually or in environment variable OPENMC_DEPLETE_CHAIN.")
             else:
-                print('Decay chain "', filename, '" is invalid.')
+                print('Decay chain "{}" is invalid.'.format(filename))
             raise
 
         for i, nuclide_elem in enumerate(root.findall('nuclide_table')):
diff --git a/openmc/deplete/openmc_wrapper.py b/openmc/deplete/openmc_wrapper.py
index c8a3bcca99..a01949a911 100644
--- a/openmc/deplete/openmc_wrapper.py
+++ b/openmc/deplete/openmc_wrapper.py
@@ -51,8 +51,8 @@ class OpenMCSettings(Settings):
     output_dir : pathlib.Path
         Path to output directory to save results.
     chain_file : str
-        Path to the depletion chain xml file.  Defaults to the
-        :envvar:`OPENDEPLETE_CHAIN` environment variable if it exists.
+        Path to the depletion chain XML file.  Defaults to the
+        :envvar:`OPENMC_DEPLETE_CHAIN` environment variable if it exists.
     dilute_initial : float
         Initial atom density to add for nuclides that are zero in initial
         condition to ensure they exist in the decay chain.  Only done for