diff --git a/Dockerfile b/Dockerfile
index 76b75150a1..b68c77acfa 100644
--- a/Dockerfile
+++ b/Dockerfile
@@ -24,9 +24,6 @@ ARG build_libmesh=off
 # By default one core is used to compile
 ARG compile_cores=1
 
-# Set default value of HOME to /root
-ENV HOME /root
-
 # OpenMC variables
 ARG openmc_branch=master
 ENV OPENMC_REPO='https://github.com/openmc-dev/openmc'
@@ -50,16 +47,10 @@ ENV DAGMC_BRANCH='develop'
 ENV DAGMC_REPO='https://github.com/svalinn/DAGMC'
 ENV DAGMC_INSTALL_DIR=$HOME/DAGMC/
 
-# LIBMESH variables
-ENV LIBMESH_TAG='v1.6.0'
-ENV LIBMESH_REPO='https://github.com/libMesh/libmesh'
-ENV LIBMESH_INSTALL_DIR=$HOME/LIBMESH
-
-# Creates the arguments for the openmc build command using parameter expansion
-ENV OPENMC_CMAKE_ARGS="-Ddebug=on -Doptimize=on -DHDF5_PREFER_PARALLEL=on -Ddagmc=${build_dagmc} -DCMAKE_PREFIX_PATH=${DAGMC_INSTALL_DIR} -Dlibmesh=${build_libmesh} -DCMAKE_PREFIX_PATH=${LIBMESH_INSTALL_DIR}"
-
 # Setup environment variables for Docker image
 ENV CC=/usr/bin/mpicc CXX=/usr/bin/mpicxx \
+    PATH=/miniconda/bin:${PATH} \
+    LIBMESH_DIR=/miniconda/libmesh \
     LD_LIBRARY_PATH=${DAGMC_INSTALL_DIR}/lib:$LD_LIBRARY_PATH \
     OPENMC_CROSS_SECTIONS=/root/nndc_hdf5/cross_sections.xml \
     OPENMC_ENDF_DATA=/root/endf-b-vii.1 \
@@ -74,6 +65,7 @@ RUN apt-get update -y && \
         libpng-dev && \
     apt-get autoremove
 
+
 # Update system-provided pip
 RUN pip install --upgrade pip
 
@@ -83,7 +75,6 @@ RUN cd $HOME && git clone --depth 1 https://github.com/njoy/NJOY2016.git && \
     cmake -Dstatic=on .. && make 2>/dev/null -j${compile_cores} install ; \
     rm -rf $HOME/NJOY2016
 
-
 RUN if [ "$build_dagmc" = "on" ]; then \
         # Install addition packages required for DAGMC
         apt-get -y install libeigen3-dev libnetcdf-dev libtbb-dev libglfw3-dev ; \
@@ -138,35 +129,56 @@ RUN if [ "$build_dagmc" = "on" ]; then \
         rm -rf ${DAGMC_INSTALL_DIR}/DAGMC ${DAGMC_INSTALL_DIR}/build ; \
     fi
 
-
 RUN if [ "$build_libmesh" = "on" ]; then \
-        # Install addition packages required for LIBMESH
-        apt-get -y install m4 libnetcdf-dev libpnetcdf-dev ; \
-        # Install LIBMESH
-        mkdir -p $HOME/LIBMESH && cd $HOME/LIBMESH ; \
-        git clone --shallow-submodules --recurse-submodules --single-branch -b ${LIBMESH_TAG} --depth 1 ${LIBMESH_REPO} ; \
-        mkdir build && cd build ; \
-        ../libmesh/configure \
-                    --prefix=${LIBMESH_INSTALL_DIR} CXX=mpicxx CC=mpicc FC=mpifort F77=mpif77 \
-                    --enable-exodus \
-                    --disable-netcdf-4 \
-                    --disable-eigen \
-                    --disable-fortran \
-                    --disable-lapack \
-                    --enable-hdf5 \
-                    --with-hdf5=/usr/lib/x86_64-linux-gnu/hdf5/serial/ \
-                    --enable-mpi ; \
-        make 2>/dev/null -j${compile_cores} install ; \
-        rm -rf ${LIBMESH_INSTALL_DIR}/build ${LIBMESH_INSTALL_DIR}/libmesh ; \
+        # Install miniconda
+        wget -q https://repo.anaconda.com/miniconda/Miniconda3-py39_4.10.3-Linux-x86_64.sh -O miniconda.sh ; \
+        bash miniconda.sh -b -p /miniconda ; \
+        rm -f miniconda.sh ; \
+        conda config --set always_yes yes --set changeps1 no ; \
+        conda update -q conda ; \
+        # Add INL public channel and install moose-libmesh
+        conda config --add channels conda-forge ; \
+        conda config --add channels https://conda.software.inl.gov/public ; \
+        conda install moose-libmesh ; \
     fi
 
 # clone and install openmc
-RUN mkdir -p $HOME/OpenMC && cd $HOME/OpenMC ; \
+RUN mkdir -p ${HOME}/OpenMC && cd ${HOME}/OpenMC ; \
     git clone --shallow-submodules --recurse-submodules -b ${openmc_branch} --depth=1 ${OPENMC_REPO} ; \
-    mkdir build && cd $HOME/OpenMC/build ; \
-    cmake ../openmc "${OPENMC_CMAKE_ARGS}" ; \
+    mkdir build && cd build ; \
+    if [ ${build_dagmc} = "on" ] && [ ${build_libmesh} = "on" ]; then \
+        cmake ../openmc \
+            -Doptimize=on \
+            -Ddebug=on \
+            -DHDF5_PREFER_PARALLEL=on \
+            -Ddagmc=on \
+            -Dlibmesh=on \
+            -DCMAKE_PREFIX_PATH="${DAGMC_INSTALL_DIR};${LIBMESH_DIR}" ; \
+    fi ; \
+    if [ ${build_dagmc} = "on" ] && [ ${build_libmesh} = "off" ]; then \
+        cmake ../openmc \
+            -Doptimize=on \
+            -Ddebug=on \
+            -DHDF5_PREFER_PARALLEL=on \
+            -Ddagmc=ON \
+            -DCMAKE_PREFIX_PATH=${DAGMC_INSTALL_DIR} ; \
+    fi ; \
+    if [ ${build_dagmc} = "off" ] && [ ${build_libmesh} = "on" ]; then \
+        cmake ../openmc \
+            -Doptimize=on \
+            -Ddebug=on \
+            -DHDF5_PREFER_PARALLEL=on \
+            -Dlibmesh=on \
+            -DCMAKE_PREFIX_PATH=${LIBMESH_DIR} ; \
+    fi ; \
+    if [ ${build_dagmc} = "off" ] && [ ${build_libmesh} = "off" ]; then \
+        cmake ../openmc \
+            -Doptimize=on \
+            -Ddebug=on \
+            -DHDF5_PREFER_PARALLEL=on ; \
+    fi ; \
     make 2>/dev/null -j${compile_cores} install ; \
     cd ../openmc && pip install -e .[test]
 
 # Download cross sections (NNDC and WMP) and ENDF data needed by test suite
-RUN $HOME/OpenMC/openmc/tools/ci/download-xs.sh
+RUN ${HOME}/OpenMC/openmc/tools/ci/download-xs.sh